1095585-40-2Relevant academic research and scientific papers
A site selective C-H arylation of free-(NH2) adenines with aryl chlorides: Application to the synthesis of 6,8-disubstituted adenines
Sahnoun, Sophian,Messaoudi, Samir,Brion, Jean-Daniel,Alami, Mouad
experimental part, p. 4271 - 4278 (2009/12/06)
An efficient site selective method for the direct arylation of free-(NH2) adenines 1 to provide a range of C-8 arylated adenines 3 in excellent yields is described. This process based on the use of Pd(OH) 2/C as the catalyst and a st
Microwave-assisted Pd(OH)2-catalyzed direct C-H arylation of free-(NH2) adenines with aryl halides
Sahnoun, Sophian,Messaoudi, Samir,Peyrat, Jean-Fran?ois,Brion, Jean-Daniel,Alami, Mouad
scheme or table, p. 7279 - 7283 (2009/04/10)
A direct C-H arylation of free-(NH2) adenines using Pd(OH)2/C (Pearlman's catalyst) and stoichiometric amount of copper iodide under ligandless microwave activation is described. This new protocol proved to be highly effective to synthesize a variety of 8-aryladenine derivatives 3 without prior protection of the amino substituent. The arylation reaction takes place rapidly within few minutes and allows the coupling to proceed regioselectively at the 8-position with a wide range of aryl halides including aryl iodides, bromides and the less reactive aryl chlorides.
