1095593-34-2Relevant academic research and scientific papers
A facile synthesis of structurally novel 1-aryl-2-arylamino-4-alkyl/phenyl-5-aroyl-1H-imidazoles from amidinothioureas
Kaila, Jitendra C.,Baraiya, Arshi B.,Vasu, Kamala K.,Sudarsanam
experimental part, p. 7220 - 7222 (2009/04/14)
We report here a convenient and efficient two-step synthesis of 1-aryl-2-arylamino-4-alkyl/phenyl-5-aroyl-1H-imidazoles from easily available amidinothioureas. Guanylation of amidinothioureas 1 using mercury(II) chloride as a thiophile yielded amidinoguanidines 2, which reacted with various phenacyl bromides under mild conditions to afford the corresponding diversely functionalized imidazoles 3 in moderate to good yields.
