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109567-63-7

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109567-63-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 109567-63-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,9,5,6 and 7 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 109567-63:
(8*1)+(7*0)+(6*9)+(5*5)+(4*6)+(3*7)+(2*6)+(1*3)=147
147 % 10 = 7
So 109567-63-7 is a valid CAS Registry Number.

109567-63-7Relevant articles and documents

Cinnamic anilides as new mitochondrial permeability transition pore inhibitors endowed with ischemia-reperfusion injury protective effect in vivo

Fancelli, Daniele,Abate, Agnese,Amici, Raffaella,Bernardi, Paolo,Ballarini, Marco,Cappa, Anna,Carenzi, Giacomo,Colombo, Andrea,Contursi, Cristina,Di Lisa, Fabio,Dondio, Giulio,Gagliardi, Stefania,Milanesi, Eva,Minucci, Saverio,Pain, Gilles,Pelicci, Pier Giuseppe,Saccani, Alessandra,Storto, Mariangela,Thaler, Florian,Varasi, Mario,Villa, Manuela,Plyte, Simon

supporting information, p. 5333 - 5347 (2014/07/08)

In this account, we report the development of a series of substituted cinnamic anilides that represents a novel class of mitochondrial permeability transition pore (mPTP) inhibitors. Initial class expansion led to the establishment of the basic structural requirements for activity and to the identification of derivatives with inhibitory potency higher than that of the standard inhibitor cyclosporine-A (CsA). These compounds can inhibit mPTP opening in response to several stimuli including calcium overload, oxidative stress, and thiol cross-linkers. The activity of the cinnamic anilide mPTP inhibitors turned out to be additive with that of CsA, suggesting for these inhibitors a molecular target different from cyclophylin-D. In vitro and in vivo data are presented for (E)-3-(4-fluoro-3-hydroxy-phenyl)-N-naphthalen-1-yl- acrylamide 22, one of the most interesting compounds in this series, able to attenuate opening of the mPTP and limit reperfusion injury in a rabbit model of acute myocardial infarction.

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