109577-45-9Relevant academic research and scientific papers
SEROTONIN REUPTAKE INHIBITORS
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Page/Page column 25, (2010/02/14)
A serotonin reuptake inhibitor which can be used in the treatment of depression and which has a decreased occurrence of unwanted side effects. The serotonin reuptake inhibitors are bi-functional organic molecules which combine serotonin transporter reuptake inhibition with serotonin (5-HT,such as 5-HT2A) receptor antagonism in one molecular entity. The serotonin-selective reuptake inhibitor (SSRI) homologue portion of the molecule shows an affinity to the serotonin reuptake transporter (SERT) and has antidepressant properties. The piperazine or piperidine portion of the molecule demonstrates an affinity to 5-HT receptors and restores the undesired side effects of SSRIs.
New benzoyl piperidine compounds
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Page/Page column 15, (2010/02/05)
Provided herein are racemic or enantiomerically enriched benzoyl piperidine compounds and pharmaceutically useful salts thereof, pharmaceutical compositions comprising an effective amount of racemic or enantiomerically enriched benzoyl piperidine compound
2-(4-BENZOYL-1-PIPERIDYL)-1-PHENYLALKANOL DERIVATIVES
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, (2008/06/13)
Compound of general formula I STR1 in which R is hydrogen, R 1 is unsubstituted phenyl, 4-methoxy-3,5-dimethylphenyl or phenyl substituted at one of the 2-, 3-or 4-positions by halogen, C 1-4 alkyl, C 1-4 alkoxy, hydroxy, benzyloxy, trifluoromethyl, cyano, nitro, amino, acetylamino, methylthio, methylsulphonyl or aminosulphonyl and R 2 is unsubstituted phenyl, 2,4,6-trimethoxyphenyl or phenyl substituted at either the 3-or the 4-positions by fluorine, chlorine, methyl or methoxy, or an acid addition salt thereof.
