109577-96-0

Basic information

• Product Name: Cyclopropanecarboxylic acid, 1-[(2-cyanoethyl)amino]- (9CI)
• Synonyms: Cyclopropanecarboxylic acid, 1-[(2-cyanoethyl)amino]- (9CI)
• CAS NO: 109577-96-0
• Molecular Formula: C7H10N2O2
• Molecular Weight: 154.1665
• Product Categories: GLYCINESCAFFOLD
• Mol File: 109577-96-0.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Cyclopropanecarboxylic acid, 1-[(2-cyanoethyl)amino]- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclopropanecarboxylic acid, 1-[(2-cyanoethyl)amino]- (9CI)(109577-96-0)
• EPA Substance Registry System: Cyclopropanecarboxylic acid, 1-[(2-cyanoethyl)amino]- (9CI)(109577-96-0)

Safety Data

• Hazardous Substances Data: 109577-96-0(Hazardous Substances Data)

Upstream product

• 22059-21-8 aminocyclopropane-1-carboxylic acid 
• 107-13-1 acrylonitrile 

Downstream Products

• 946497-95-6 tert-butyl 3'-amino-1'H-spiro[cyclopropane-1,6'-pyrrolo[3,4-c]pyrazole]-5'(4'H)-carboxylate 

Relevant articles and documents

INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7)

The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for treating and/or preventing proliferative diseases (e.g., cancers (e.g., leukemia, acute lymphoblastic leukemia, lymphoma, Burkitt's lymphoma, melanoma, multiple myeloma, breast cancer, Ewing's sarcoma, osteosarcoma, brain cancer, neuroblastoma, lung cancer, colorectal cancer), benign neoplasms, diseases associated with angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of a kinase, such as a cyclin-dependent kinase (CDK) (e.g., cyclin-dependent kinase 7 (CDK7)), and therefore, induce cellular apoptosis and/or inhibit transcription in the subject.