1095873-95-2Relevant academic research and scientific papers
Cascade aza-Wittig/6π-Electrocyclization in the Synthesis of 1,6-Dihydropyridines
Polychronidou, Vasiliki,Krupp, Anna,Strohmann, Carsten,Antonchick, Andrey P.
, p. 6024 - 6029 (2021)
A metal-free protocol for the synthesis of substituted 1,6-dihydropyridines with quaternary stereogenic centers via a cascade aza-Wittig/6π-electrocyclization process has been developed. The high functional group compatibility and broad scope of this method were demonstrated by using a wide range of easily available vinyliminophosphoranes and ketones, with yields up to 97%. A modification of the obtained products allowed for an increase in complexity and chemical diversity. Finally, attempts for asymmetric synthesis of 1,6-dihydropyridines are demonstrated.
A cascade approach to pyridines from 2-Azido-2,4-dienoates and α-diazocarbonyl compounds
Chen, Zheng-Bo,Hong, Deng,Wang, Yan-Guang
supporting information; experimental part, p. 903 - 905 (2009/06/20)
A one-pot synthesis of substituted pyridines via a cascade reaction of 2-azido-2,4-dienoates with α-diazocarbonyl compounds and triphenylphosphine is reported. The process involves a Staudinger-Meyer reaction, a Wolff rearrangement, an aza-Wittig reaction, and an electrocyclic ring- closure. The procedure is general and efficient. The substrates are readily available.
