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1095874-89-7

Aurora 937, also known as 4-(4-nitrophenyl)-2,4-dioxobutanoic acid, is a chemical compound with the molecular formula C10H7NO6. It is a white crystalline solid that is soluble in water and has a molecular weight of 243.17 g/mol. Aurora 937 is a potent and selective inhibitor of the enzyme dihydroorotate dehydrogenase (DHODH), which plays a crucial role in the de novo pyrimidine synthesis pathway. This enzyme is essential for the proliferation of rapidly dividing cells, such as cancer cells and certain pathogens, making Aurora 937 a potential therapeutic agent for the treatment of various diseases, including cancer and viral infections. The compound has been extensively studied for its potential applications in medicine, and ongoing research continues to explore its efficacy and safety in clinical settings.

1095874-89-7

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1095874-89-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1095874-89-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,9,5,8,7 and 4 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1095874-89:
(9*1)+(8*0)+(7*9)+(6*5)+(5*8)+(4*7)+(3*4)+(2*8)+(1*9)=207
207 % 10 = 7
So 1095874-89-7 is a valid CAS Registry Number.

1095874-89-7Upstream product

1095874-89-7Downstream Products

1095874-89-7Relevant articles and documents

Synthesis of Analogs of Trans-Fagaramide and Their Cytotoxic Activity

Tomas, Melissa Barrera,Shiao, Tze Chieh,Nguyen, Phuong Trang,Bourgault, Steve,Roy, René

, p. 995 - 1004 (2018)

A series of 30 compounds were synthetized inspired by active trans-fagaramide structure skeleton. On this synthetic platform, 18 compounds were achieved via Knoevenagel condensation using maleic acid and piperonal, followed by peptide coupling with various amines, giving an average yield of 54%. Subsequently, nine compounds were obtained by palladium-mediated Heck coupling with an average yield of 79%. In addition, cytotoxic activity was evaluated against cardiomyoblast H9c2, breast adenocarcinoma MCF7, hepatocellular carcinoma HepG2, and glioblastoma U-87 cells. The results revealed two aryl halogen-substituted compounds moderately active against H9c2 and MCF7 with IC50 values > 50 μM. One functionalized coumarin showed inhibitory activity against H9c2 (IC50 > 50 μM). In contrast, p-aminophenyl-β-monosubstituted trans-fagaramide was found to inhibit MCF7 (IC50 > 50 μM) without showing toxicity against H9c2 cells.

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