109598-98-3

Upstream product

• 93-40-3 (3,4-Dimethoxyphenyl)acetic acid 
• 95-01-2 2,4-Dihydroxybenzaldehyde 
• 1131-62-0 1-(3,4-dimethoxyphenyl)ethanone 
• 6296-57-7 7-acetoxy-3-(3,4-dimethoxyphenyl)chromen-2-one 

Downstream Products

• 869080-07-9 3-(3,4-dimethoxyphenyl)-7-(2-oxopropoxy)chromen-2-one 
• 717894-43-4 3-(3,4-dimethoxyphenyl)-7-(2-oxo-2-phenylethoxy)chromen-2-one 
• 1217515-18-8 (1R,5S)-3-([7-hydroxy-3-(3,4-dimethoxyphenyl)-2-oxo-2H-chromen-8-yl]methyl)-1,2,3,4,5,6-hexahydro-8H-1,5-methanopyrido[1,2-a][1,5]diazocin-8-one 
• 1146938-71-7 7-(2-bromoethoxy)-3-(3,4-dimethoxyphenyl)-2H-chromen-2-one 

Relevant academic research and scientific papers

Synthesis and biological evaluation of 3-arylcoumarin derivatives as potential anti-diabetic agents

A variety of substituted 3-arylcoumarin derivatives were synthesised through microwave radiation heating. The method has characteristics of environmental friendliness, economy, simple separation, and purification process, less by-products and high reaction yield. Those 3-arylcoumarin derivatives were screened for antioxidant, α-glucosidase inhibitory and advanced glycation end-products (AGEs) formation inhibitory. Most compounds exhibited significant antioxidant and AGEs formation inhibitory activities. Anti-diabetic activity studies showed that compounds 11 and 17 were equipotent to the standard drug glibenclamide in vivo. According to the experimental results, the target compound 35 can be used as a lead compound for the development of new anti-diabetic drugs. The whole experiment showed that anti-diabetic activity is prevalent in 3-arylcoumarins, which added a new natural skeleton to the development of anti-diabetic active drugs.

Decarboxylation of α,β-unsaturated aromatic lactones: Synthesis of: E-ortho -hydroxystilbenes from 3-arylcoumarins or isoaurones

A simple and environmentally friendly strategy for the synthesis of E-ortho-hydroxystilbenes has been established. Two kinds of α,β-unsaturated aromatic lactones, i.e. the 3-arylcoumarins and the isoaurones, could both readily undergo a cascade hydrolyzation/decarboxylation reaction in the presence of KOH in ethylene glycol to afford the desired E-ortho-hydroxystilbenes in moderate to high yields.

Design, synthesis and evaluation of novel multi-target-directed ligands for treatment of Alzheimer's disease based on coumarin and lipoic acid scaffolds

A novel series of coumarin-lipoic acid conjugates were synthesized via cycloaddition click reaction to find out new multi-target-directed ligands (MTDLs) for treatment of Alzheimer's disease (AD). All of synthesized compounds were screened for neuroprotec

Synthesis of flavonoid derivatives of cytisine. 1. Aminomethylation of 7-hydroxy-3-arylcoumarins

Aminomethylation involving the natural alkaloid (-)-cytisine of analogs of natural 3-arylbenzopyran-2-ones was studied. Substituted 8-(cytisin-12-yl) methyl-3-aryl-7-hydroxycoumarins were synthesized.

Modified coumarins. 29. Synthesis of structural analogs of natural 6-arylfuro[3,2-g]chromen-7-ones

3-Substituted 6-arylfuro[3,2-g]chromen-7-ones, structural analogs of natural furocoumarins, were synthesized by linear annelation of a furan fragment to a 3-arylcoumarin system.