1096017-27-4Relevant articles and documents
Organocatalytic asymmetric aziridination of enones
Pesciaioli, Fabio,De Vincentiis, Francesco,Galzerano, Patrizia,Bencivenni, Giorgio,Bartoli, Giuseppe,Mazzanti, Andrea,Melchiorre, Paolo
, p. 8703 - 8706 (2008)
A primary amine derived from cinchona alkaloids as a salt with d-N-Boc phenylglycine (Boc = tert-butoxycarbonyl) is an efficient catalyst for the aziridination of α,β-unsaturated ketones. This method is effective with both linear and cyclic substrates, leading to chiral aziridines in high yield, with complete diastereoselectivity, and with very high enantioselectivity (Cbz = benzyloxycarbonyl).