109613-93-6Relevant articles and documents
A concise approach towards the synthesis of WS75624 a and WS75624 B via the cross-metathesis of vinyl-functionalized thiazoles
Dash, Jyotirmayee,Melillo, Bruno,Arseniyadis, Stellios,Cossy, Janine
, p. 2246 - 2249 (2011/05/05)
Synthetic approach towards precursors of WS75624 A and WS75624 B, two potent endothelin converting enzyme (ECE) inhibitors and potential antihypertensive agents, is reported featuring a key cross-metathesis between a vinyl-functionalized thiazole and a terminal olefin. As the two natural products only differ by the nature of their hydroxyalkyl side-chain, our convergent strategy enable the synthesis of key intermediates of both molecules in a limited amount of steps.
UK-2A, B, C and D, novel antifungal antibiotics from Streptomyces sp. 517-02. III. Absolute configuration of an antifungal antibiotic, UK-2A, and consideration of its conformation
Shibata, Kozo,Hanafi, Muhammad,Fujii, Jyunko,Sakanaka, Osamu,Iinuma, Katsuharu,Ueki, Masashi,Taniguchi, Makoto
, p. 1113 - 1116 (2007/10/03)
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Syntheses of Hydroxylated Bipyridines, I. - Orellanine, the Poison of a Toadstool
Dehmlow, Eckehard V.,Schulz, Hans-Joachim
, p. 857 - 862 (2007/10/02)
Two syntheses of orellanine, -3,3',4,4'-tetrol-1,1'-dioxide (5b), are developed which comprise 10 or 11 steps, respectively.The chemical reactions of 5b with diazomethane and on UV irradiation are described.