1096155-52-0Relevant academic research and scientific papers
Structural elucidation of propargylated products of 3-substituted-1,2, 4-triazole-5-thiols by NMR techniques
Chaudhary, Preeti M.,Chavan, Sayalee R.,Kavith,Maybhate, Shailaja P.,Deshpande, Sunita R.,Likhite, Anjali P.,Rajamohanan
experimental part, p. 1168 - 1174 (2009/05/26)
Propargylation of 3-substituted-1,2,4-triazole-5-thiols, which predominantly exist as their thione tautomers, was carried out with the view to synthesize different heterocycles and study their biological activity. Three different products namely, a mono S-propargyl and two S,N-dipropargyl regioisomers, arising from N1/N2 substitution, were isolated and characterized. Unambiguous structural elucidation of the regioisomers of S,N-dipropargyl derivatives was achieved by means of 13C-1H HMBC technique. The proportion of the regioisomers was found to vary with the substituent on the 1,2,4-triazole thiols. No product corresponding to N4 substitution was isolated from any of the reactions carried out. Copyright
