1096155-96-2Relevant academic research and scientific papers
Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK)
Farmer, Luc J.,Bemis, Guy,Britt, Shawn D.,Cochran, John,Connors, Martin,Harrington, Edmund M.,Hoock, Thomas,Markland, William,Nanthakumar, Suganthini,Taslimi, Paul,Haar, Ernst Ter,Wang, Jian,Zhaveri, Darshana,Salituro, Francesco G.
scheme or table, p. 6231 - 6235 (2009/08/07)
A series of SYK inhibitors based on the phenylamino pyrimidine thiazole lead 4 were prepared and evaluated for biological activity. Lead optimization provided compounds with nanomolar Ki's against SYK and potent inhibition in mast cell degranulation assays.
