1096157-75-3Relevant academic research and scientific papers
A novel, one-pot, efficient synthesis of 2-aroyl-1,4-diaryl-7,9-dimethyl-7, 9-diazaspiro[4.5]deca-1,3-diene-6,8,10-triones
Adib, Mehdi,Sayahi, Mohammad Hosein,Ziyadi, Hakimeh,Zhu, Long-Guan,Bijanzadeh, Hamid Reza
experimental part, p. 3289 - 3294 (2009/05/11)
A novel and efficient synthesis of 2-aroyl-1,4-diaryl-7,9-dimethyl-7,9- diazaspiro[4.5]deca-1,3-diene-6,8,10-triones is described. The reactive 1:1 zwitterionic intermediate, formed by the addition of triphenylphosphine to diaroylacetylenes, was trapped by a Knoevenagel condensation product prepared in situ by reaction of AyV-dimethylbarbituric acid and aromatic aldehydes, to afford the title compounds in excellent yields under mild reaction conditions.
