109619-21-8Relevant articles and documents
CYCLIZATION OF NITRILES. XXI. SUBSTITUTED 4-(3-PYRIDYL)- AND 4-(4-PYRIDYL)-3-CYANO-2(1H)-PYRIDINETHIONES
Sharanin, Yu. A.,Shestopalov, A. M.,Litvinov, V. P.,Mortikov, V. Yu.,Rodinovskaya, L. A.,et. al.
, p. 1762 - 1770 (2007/10/02)
The reaction of pyridylmethylenecyanothioacetamides with carbonyl compounds, enamines, and enamino ketones gave substituted 4-(3-pyridyl)- and 4-(4-pyridyl)-3-cyano-2(1H)-pyridinethiones and their hydrogenated analogs.The direction of the transformation is determined by the structure of the initial reagents.From a detailed study of the reactions a method was developed for the synthesis of derivatives of 4-(3-pyridyl)- and 4-(4-pyridyl)-3-cyano-2(1H)-pyridinethiones involving three-component condensation of aldehydes of the pyridine series, carbonyl compounds, and cyanothioacetamide.