109635-36-1Relevant academic research and scientific papers
Palladium/Rhodium Cooperative Catalysis for the Production of Aryl Aldehydes and Their Deuterated Analogues Using the Water–Gas Shift Reaction
Ibrahim, Malek Y. S.,Denmark, Scott E.
supporting information, p. 10362 - 10367 (2018/07/31)
A novel Pd/Rh dual-metallic cooperative catalytic process has been developed to effect the reductive carbonylation of aryl halides in moderate to good yield. In this reaction, water is the hydride source, and CO serves both as the carbonyl source and the terminal reductant through the water–gas shift reaction. The catalytic generation of the Rh hydride allows for the selective formation of highly hindered aryl aldehydes that are inaccessible through previously reported reductive carbonylation protocols. Moreover, aldehydes with deuterated formyl groups can be efficiently and selectively synthesized using D2O as a cost-effective deuterium source without the need for presynthesizing the aldehyde.
One-Pot Synthesis of Deuterated Aldehydes from Arylmethyl Halides
Li, Xiangmin,Wu, Shanchao,Chen, Shuqiang,Lai, Zengwei,Luo, Hai-Bin,Sheng, Chunquan
supporting information, p. 1712 - 1715 (2018/04/14)
A facile, one-pot approach for synthesizing deuterated aldehydes from arylmethyl halides was developed using D2O as the deuterium source. The efficient process is realized by a sequence of formation, H/D exchange, and oxidation of pyridinium salt intermediates. The mild and air-compatible reaction conditions enable efficient synthesis of diverse deuterated aldehydes with high deuterium incorporation.
Chiral Thioureas Promote Enantioselective Pictet-Spengler Cyclization by Stabilizing Every Intermediate and Transition State in the Carboxylic Acid-Catalyzed Reaction
Klausen, Rebekka S.,Kennedy, C. Rose,Hyde, Alan M.,Jacobsen, Eric N.
, p. 12299 - 12309 (2017/09/12)
An investigation of the mechanism of benzoic acid/thiourea co-catalysis in the asymmetric Pictet-Spengler reaction is reported. Kinetic, computational, and structure-activity relationship studies provide evidence that rearomatization via deprotonation of
A Novel Thermal Decomposition of α-Methylthiobenzyl Phenyl Sulfones. Synthesis of p-Substituted 1-Deuteriobenzaldehydes
Wladislaw, B.,Marzorati, L.,Uchoa, R. B.
, p. 964 - 965 (2007/10/02)
Thermal decomposition of some α-methylthio-p-substituted benzyl sulfones afforded p-substituted benzaldehydes and 1-deuteriobenzaldehydes in good yields, irrespective of the electronic character of the p-substituents.The formation and subsequent decomposition of an intermediate sulfinic ester are discussed.
