109635-75-8Relevant academic research and scientific papers
(Phosphinyloxy)acyl amino acid inhibitors of angiotensin converting enzyme (ACE). 1. Discovery of (S)-1-[6-amino-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxohexyl]- -proline, a novel orally active inhibitor of ACE
Karanewsky,Badia,Cushman,DeForrest,Dejneka,Loots,Perri,Petrillo Jr.,Powell
, p. 204 - 212 (2007/10/02)
The synthesis of a series of orally active, phosphinyloxyacyl proline inhibitors of angiotensin converting enzyme (ACE) is described. The in vitro and in vivo ACE inhibitory activities are reported for each compound. The structure-activity relationship fo
ORALLY ACTIVE PHOSPHONYL HYDROXYACYL PROLINES
-
, (2008/06/13)
This invention is directed to orally active antihypertensive agents of the formula STR1 wherein R 1 is certain alkyl or aralkyl groups.
