1096481-48-9

Basic information

• Product Name: 2-Amino-5-iodo-3-methylbenzoic Acid Methyl Ester
• Synonyms: 2-Amino-5-iodo-3-methylbenzoic Acid Methyl Ester
• CAS NO: 1096481-48-9
• Molecular Formula: C9H10INO2
• Molecular Weight: 291.08567
• Mol File: 1096481-48-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 352.4±42.0 °C(Predicted)
• Appearance: /
• Density: 1.733±0.06 g/cm3(Predicted)
• Storage Temp.: -20°C Freezer
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 1.71±0.10(Predicted)
• CAS DataBase Reference: 2-Amino-5-iodo-3-methylbenzoic Acid Methyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-5-iodo-3-methylbenzoic Acid Methyl Ester(1096481-48-9)
• EPA Substance Registry System: 2-Amino-5-iodo-3-methylbenzoic Acid Methyl Ester(1096481-48-9)

Safety Data

• Hazardous Substances Data: 1096481-48-9(Hazardous Substances Data)

Usage

Uses

2-Amino-5-iodo-3-methylbenzoic Acid Methyl Ester is an substituent in the synthesis of analogs of Rilpivirine (R509800), a novel non-nucleoside reverse transcriptase inhibitor.

Upstream product

• 67-56-1 methanol 
• 108857-24-5 2-amino-5-iodo-3-methylbenzoic acid 
• 22223-49-0 methyl 2-amino-3-methylbenzoate 
• 18107-18-1 diazomethyl-trimethyl-silane 

Downstream Products

• 1007113-24-7 methyl 2-amino-5-methoxy-3-methyl benzoate 

Relevant articles and documents

Synthesis and anti-oomycete activity of novel quinazolin- and benzothiazol-6-yloxyacetamides: Potent aza-analogs and five-ring analogs of quinoline fungicides

Novel quinazolin- and benzothiazol-6-yloxyacetamides show excellent in vivo activity against the three economically most important Oomycete pathogens Phytophthora infestans, Plasmopara viticola and Pythium ultimum. They are polar analogs of known quinolin-6-yloxyacetamides, which are not active against the soil-borne damping-off disease caused by Pythium ultimum. The Bogert quinazoline synthesis, an almost forgotten heterocyclization technique, proved to be highly useful for the concise construction of required quinazolin-6-ol building blocks.

HETEROBICYCLIC AMIDES AS INHIBITORS OF CD38

The present invention relates to heterobicyclic amides and related compounds which are inhibitors of CD38 and are useful in the treatment of cancer.