1096706-56-7Relevant articles and documents
Novel berberine triazoles: Synthesis, antimicrobial evaluation and competitive interactions with metal ions to Human Serum Albumin
Zhang, Shao-Lin,Chang, Juan-Juan,Damu, Guri L.V.,Fang, Bo,Zhou, Xiang-Dong,Geng, Rong-Xia,Zhou, Cheng-He
, p. 1008 - 1012 (2013/03/14)
A series of novel berberine triazoles were synthesized and characterized by IR, NMR, MS and HRMS spectra. All target compounds and their precursors were screened for antimicrobial activities in vitro against four Gram-positive bacteria, four Gram-negative bacteria and two fungal strains. Bioactive assay indicated that most of the prepared compounds exhibited good antibacterial and antifungal activities with low MIC values ranging from 2 to 64 μg/mL, which were comparable to or even better than the reference drugs Berberine, Chloromycin, Norfloxacin and Fluconazole. The competitive interactions between compound 5a and metal ions to Human Serum Albumin (HSA) revealed that the participation of Mg2+ and Fe3+ ions in compound 5a-HSA association could result in the concentration increase of free compound 5a, shorten the storage time and half-life of compound 5a in the blood, thus improving its antimicrobial efficacy.
Synthesis and biological activities of novel amine-derived bis-azoles as potential antibacterial and antifungal agents
Fang, Bo,Zhou, Cheng-He,Rao, Xian-Cai
experimental part, p. 4388 - 4398 (2010/10/02)
A series of novel amine-derived bis-azole compounds were designed by the systematical structural modification of Fluconazole and synthesized by a convenient and efficient method, and the antimicrobial activities for all prepared compounds were evaluated i