109681-06-3

Upstream product

• 123973-59-1 2-(methylsulfonyl)ethyl 6'-bromo-4-<(chloroacetyl)oxy>-1',2'-dihydro-3-hydroxy-5-methyl-3-<<<5-nitro-2,6-bis(phenylmethoxy)-4-pyrimidinyl>amino>methyl>-2'-oxospiro-indole>-2-carboxylate 
• 123973-60-4 2-(methylsulfonyl)ethyl 6'-bromo-4-<(chloroacetyl)oxy>-1',2'-dihydro-5-methyl-3-<<<5-nitro-2,6-bis(phenylmethoxy)-4-pyrimidinyl>amino>methyl>-2'-oxospiro<2-cyclopentene-1,3'-<3H>indole>-2-carboxylate 
• 123973-58-0 2-(methylsulfonyl)ethyl 6'-bromo-1',2'-dihydro-3,4-dihydroxy-5-methyl-3-<<<5-nitro-2,6-bis(phenylmethoxy)-4-pyrimidinyl>amino>methyl>-2'-oxospiroindole>-2-carboxylate 
• 124059-45-6 2-(methylsulfonyl)ethyl 6'-bromo-1',2'-dihydro-4-hydroxy-5-methyl-3-<<<5-nitro-2,6-bis(phenylmethoxy)-4-pyrimidinyl>amino>methyl>-2'-oxospiro<2-cyclopentene-1,3'-<3H>indole>-2-carboxylate 
• 123973-57-9 2-(methylsulfonyl)ethyl 6'-bromo-1',2'-dihydro-5-methyl-3-<<<5-nitro-2,6-bis(phenylmethoxy)-4-pyrimidinyl>amino>methyl>-2'-oxospiro<3-cyclopentene-1,3'-<3H>indole>-2-carboxylate 
• 123973-54-6 2-(methylsulfonyl)ethyl 6'-bromo-1',2'-dihydro-5-methyl-3-<<(methylsulfonyl)oxy>methyl>-2'-oxospiro<3-cyclopentene-1,3'-<3H>indole>-2-carboxylate 
• 123973-53-5 2-(methylsulfonyl)ethyl 6'-bromo-3-formyl-1',2'-dihydro-5-methyl-2'-oxospiro<3-cyclopentene-1,3'-<3H>indole>-2-carboxylate 
• 123973-56-8 C₁₈H₂₁BrN₂O₅S 
• 143101-47-7 2-(methylsulfonyl)ethyl 6'-bromo-1',2'-dihydro-3-hydroxymethyl-5-methyl-2'-oxospiro<3-cyclopentene-1,3'-<3H>indole>-2-carboxylate 
• 143101-46-6 2-(methylsulfonyl)ethyl 6'-bromo-1',2'-dihydro-6-methyl-2'-oxospiro<4-cyclohexene-1,3'-<3H>indole>-2-carboxylate 
• 123999-63-3 ethyl 6'-bromo-1',2'-dihydro-6-methyl-2'-oxospiro<4-cyclohexene-1,3'-<3H>indole>-2-carboxylate 
• 123973-50-2 6'-bromo-1,2'-dihydro-6-methyl-2'-oxospiro<4-cyclohexene-1,3'-<3H>indole>-2-carboxylic acid 
• 42839-50-9 (E)-6-bromo-3-ethoxycarbonylmethylene-2-oxoindoline 
• 6326-79-0 6-bromoisatin 

Downstream Products

• 109714-13-8 C₅₄H₆₂BrN₅O₁₇ 
• 109681-07-4 C₆₄H₇₂BrN₅O₂₂ 
• 109714-11-6 1'-acetyl-6-(acetyloxy)-6'-bromo-1',2',8,8a,9,10-hexahydro-6-methyl-2'-oxo-2,4-bis(phenylmethoxy)spiropyrimido<4,5-b><1,4>diazepine-7(6H),3'-<3H>indole>-8-carboxylic acid 

Relevant academic research and scientific papers

Second approach to the construction of a pentacyclic ring system for neosurugatoxin

The Diels-Alder adduct obtained from (E)-6-bromo-3-ethoxycarbonylmethylene-2-oxoindoline and trans-1,3-pentadiene was successfully transformed into the diacetate of the aglycone of neosurugatoxin, which is the key intermediate in our first total synthesis

TOTAL SYNTHESIS OF NEOSURUGATOXIN

Total synthesis of neosurugatoxin, having a strong affinity for nicotinic receptors, is described.