109683-76-3Relevant academic research and scientific papers
1,3,4-THIADIAZOLES
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, (2008/06/13)
There are described compounds of formula I, STR1 in which Y is S, O or NR 9,n is 0 or 1,R. sub.9 is hydrogen or alkyl C 1 to 10,R 3 is hydrogen, alkyl C 1 to 10, cycloalkyl C3 to 10, CF 3, SR 10, a 5 or 6 membered heterocyclic group containing one or more S, O or N atoms, NR 4 R 5, phenyl or phenylalkyl C7 to 12, the phenyl, phenylalkyl and heterocyclic groups optionally being fused to a further phenyl group, the heterocyclic group and any phenyl group optionally being substituted by alkyl C 1 to 6, halogen, alkoxy C 1 to 6, nitro, nitrile, CF 3, SR. sub.6, NR 7 R 11 or hydroxy,R 6, R 7 and R 11, which may be the same or different, are each hydrogen or alkyl C 1 to 10,R. sub.4 and R 5, which may be the same or different, are each hydrogen, alkyl C 1 to 10 or phenyl, R 10 is alkyl C 1 to 10, X 1 is S or O, andA is a chain comprising from 2-16 atoms, which chain carries an O or S containing substitutent at a position 2-6 atoms away from the group C=X 1,and pharmaceutically acceptable salts, esters and amides thereof, p1 there are also described method of making the compounds and pharmaceutical formulations, e.g. for the treatment of hypertension, containing them.
