109686-38-6Relevant academic research and scientific papers
Construction of Quaternary Stereocenters by Nickel-Catalyzed Heck Cyclization Reactions
Desrosiers, Jean-Nicolas,Hie, Liana,Biswas, Soumik,Zatolochnaya, Olga V.,Rodriguez, Sonia,Lee, Heewon,Grinberg, Nelu,Haddad, Nizar,Yee, Nathan K.,Garg, Neil K.,Senanayake, Chris H.
, p. 11921 - 11924 (2016/11/16)
A nickel-catalyzed Heck cyclization for the construction of quaternary stereocenters is reported. This transformation is demonstrated in the synthesis of 3,3-disubstituted oxindoles, which are prevalent motifs seen in numerous biologically active molecules. The method shows broad scope, proceeds in synthetically useful yields, and provides a rare means to construct stereochemically complex frameworks by nonprecious-metal catalysis.
