109690-46-2

Usage

Complex structure

The compound has a complex structure that includes a beta-carboline backbone and a carboxylic acid functional group.

Beta-carboline derivative

It is a derivative of the beta-carboline alkaloid family, which is known for its potential psychoactive and medicinal properties.

Ethylated version

This particular compound is an ethylated version of the beta-carboline structure, which may affect its biological activity and pharmacological properties.

Potential as a drug

The presence of the carboxylic acid group suggests that it may have potential as a drug or pharmaceutical ingredient, as carboxylic acids are commonly used in drug formulations for their ability to improve solubility, stability, and bioavailability.

Ongoing research

Research on 1-ETHYL-2,3,4,9-TETRAHDRO-1H-BETA-CARBOLINE-3-CARBOXYLIC ACID is ongoing to further understand its potential uses and effects.

InChI:InChI=1/C14H16N2O2/c1-2-10-13-9(7-12(15-10)14(17)18)8-5-3-4-6-11(8)16-13/h3-6,10,12,15-16H,2,7H2,1H3,(H,17,18)

Upstream product

• 123-38-6 propionaldehyde 
• 73-22-3 L-Tryptophan 
• 54-12-6 Trp 
• 73327-08-9 cis-(3-(methoxycarbonyl)-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indol-1-yl)(1-ethane) 
• 73327-08-9 trans-(3-(methoxycarbonyl)-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indol-1-yl)(1-ethane) 

Relevant academic research and scientific papers

Discovery of pyridoindole derivatives as potential inhibitors for phosphodiesterase 5A: in silico and in?vivo studies

The aim of this work was to synthesise derivatives from identified plant based pyridoindole lead scaffold, and to assess phosphodiesterase 5A inhibitory potential by in silico and in?vivo. Pyridoindole derivatives were synthesised by using six-stage reactor. In silico screening was carried out by grip-based docking methodology. In step-I, tryptophan as a starting material was reacted with different aldehydes and ketones to obtain 11 molecules. In step-II, obtained molecules were reacted with ethanol and benzyl alcohols to obtain D1 to D22 derivatives. In silico investigation resulted in best three molecules D12, D4 and D8 with promising BE score. Oral acute toxicity study of selected molecules resulted in LD50 value 500 mg/kg in rats. The result of in?vivo antihypertensive study shown that molecule D12 was found to be the best antihypertensive lead molecule. This study could be a best platform to tailor novel biomolecules for inhibiting phosphodiesterase 5A enzyme in hypertension management.

HARMINE DERIVATIVES, INTERMEDIATES USED IN THEIR PREPARATION, PREPARATION PROCESSES AND USE THEREOF

This invention relates to compounds of general formula (I), wherein R1, R2, R3, R4 and R5 are as defined specification; intermediates used in their preparation, preparation processes and use thereof. The present invention produce harmine derivatives with enhanced antihumour activity and lower nervous system toxicity by structurally modification parent structure of β-carboline of harmines at position 1, 2, 3, 7 and 9, The compounds of the present invention can be pre easily with high yield. They can be used in manufacture of a variety of antitumour medicines and medicines used in treatm tumour diseases in combination of light or radiation therapy.