1096900-80-9Relevant academic research and scientific papers
Design, Synthesis, and Conformational Analysis of Oligobenzanilides as Multifacial α-Helix Mimetics
Flack, Theo,Romain, Charles,White, Andrew J. P.,Haycock, Peter R.,Barnard, Anna
, p. 4433 - 4438 (2019/06/27)
The design, synthesis, and conformational analysis of an oligobenzanilide helix mimetic scaffold capable of simultaneous mimicry of two faces of an α-helix is reported. The synthetic methodology provides access to diverse monomer building blocks amenable to solid-phase assembly in just four synthetic steps. The conformational flexibility of model dimers was investigated using a combination of solid and solution state methodologies supplemented with DFT calculations. The lack of noncovalent constraints allows for significant conformational plasticity in the scaffold, thus permitting it to successfully mimic residues i, i+2, i+4, i+6, i+7, and i+9 of a canonical α-helix.
Solid-phase methodology for synthesis of O-alkylated aromatic oligoamide inhibitors of α-helix-mediated protein-protein interactions
Murphy, Natasha S.,Prabhakaran, Panchami,Azzarito, Valeria,Plante, Jeffrey P.,Hardie, Michaele J.,Kilner, Colin A.,Warriner, Stuart L.,Wilson, Andrew J.
, p. 5546 - 5550 (2013/06/27)
Rapid access to rigid rods: A method is described for the synthesis of 3-O-alkylated aromatic oligobenzamide foldamers that could be used for assembly of libraries of α-helix mimetic inhibitors of protein-protein interactions (see scheme; Fmoc=9-fluorenyl
