1097128-80-7

Upstream product

• 769126-80-9 methyl 4,6-O-benzylidene-3-deoxy-3-C-(3-hydroxypropyl)-α-D-altopyranoside 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Downstream Products

• 1030028-14-8 methyl 4,6-O-benzylidene-2-O-(tert-butyldimethylsilyl)-3-C-{3-(tert-butyldiphenylsilyloxy)propyl}-3-deoxy-α-D-altopyranoside 

Relevant academic research and scientific papers

The 2α-(3-hydroxypropyl) group as an active motif in vitamin D3 analogues as agonists of the mutant vitamin D receptor (Arg274Leu)

We designed and synthesized 1α- and 1β-hydroxymethyl-2α-(3-hydroxypropyl)-25-hydroxyvitamin D3 (2a,b) and related analogues 2α-(3-hydroxypropyl)-25-hydroxyvitamin D3 (3), Posner's analogues of 1α- and 1β-hydroxymethyl-25-hydroxyvitamin D3 (4a,b), as well as 2α-(3-hydroxypropyl)-1α,25-dihydroxyvitamin D3 (5), to confirm the effect of the 1α-hydroxy group and/or 2α-(3-hydroxypropyl) group of vitamin D3 analogues with the modified A-ring moiety on the mutant vitamin D receptor, VDR(Arg274Leu). The 2α-(3-hydroxypropyl) group showed better effect on enhancement of the transcriptional activity through the mutant VDR than the 1α- and 1β-hydroxymethyl groups.