109716-83-8

Basic information

• Product Name: arteether
• Synonyms: beta-Artether
• CAS NO: 109716-83-8
• Molecular Formula: C₁₇H₂₈O₅
• Molecular Weight: 0
• Mol File: 109716-83-8.mol

Chemical Properties

• Boiling Point: 372.4°C at 760 mmHg
• Flash Point: 146°C
• Appearance: /
• Density: 1.16g/cm³
• Vapor Pressure: 2.06E-05mmHg at 25°C
• Refractive Index: 1.516
• CAS DataBase Reference: arteether(CAS DataBase Reference)
• NIST Chemistry Reference: arteether(109716-83-8)
• EPA Substance Registry System: arteether(109716-83-8)

Safety Data

• Hazardous Substances Data: 109716-83-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Arteether is used as an antimalarial drug for treating malaria caused by Plasmodium falciparum, the parasite responsible for the most severe form of the disease. It is particularly effective against multidrug-resistant strains, making it a vital tool in combating malaria in areas where resistance to other antimalarial drugs is a concern.
Used in Healthcare Settings:
Arteether is used as a fast-acting and highly efficacious medication for clearing malaria parasites from the bloodstream and preventing the development of the disease. Its rapid action and high efficacy make it a preferred choice for healthcare professionals in treating severe malaria cases, especially when resistance to other antimalarial drugs is present.

InChI:InChI=1/C17H28O5/c1-5-18-14-11(3)13-7-6-10(2)12-8-9-16(4)20-15(19-14)17(12,13)22-21-16/h10-15H,5-9H2,1-4H3/t10-,11-,12+,13+,14?,15-,16-,17-/m1/s1

Upstream product

• 64-17-5 ethanol 

Downstream Products

• 129371-40-0 (R)-2-((1S,4R)-4-Methyl-7-oxo-1,2,3,4,4a,5,6,7-octahydro-naphthalen-1-yl)-propionaldehyde 

Related news

Repetitive live sporozoites inoculation under arteether (cas 109716-83-8) chemoprophylaxis confers protection against subsequent sporozoite challenge in rodent malaria model07/23/2019

Inoculation with live sporozoites under prophylactic antimalarial cover (CPS-immunization) represents an alternate approach to develop sterile, reproducible, and long-term protection against malaria. Here, we have employed arteether (ART), a semi synthetic derivative of artemisinin to explore it...detailed

Assessment of in vivo antimalarial activity of arteether (cas 109716-83-8) and garlic oil combination therapy07/22/2019

The study evaluates in vivo antimalarial activity of arteether and garlic pearl oil combination in Plasmodium berghei-infected mouse model of malaria. 72 h (Day 3) post infection, at 2–4% parasitemia, mice were treated with single dose intramuscular injection of α-β arteether, at 750 μg, in ...detailed

Relevant articles and documents

PREPARATIVE PROCESS FOR ETHER DERIVATIVE OF ARTEMISININ

The present invention relates to a process for synthesis of ether derivative of artemisinin by reducing artemisinin to dihydroartemisinin using a mixture of sodium borohydride and a dihydroxy compound, followed by etherification in presence of an acid catalyst and an alcohol.