109720-89-0Relevant academic research and scientific papers
The Asymmetric Aza-silyl-Prins Reaction: Synthesis of Enantiopure Piperidines
Mittapalli, Ramana R.,Guesné, Sebastien J. J.,Parker, Robert J.,Klooster, Wim T.,Coles, Simon J.,Skidmore, John,Dobbs, Adrian P.
, p. 350 - 355 (2019)
The design and development of the first asymmetric aza-silyl-Prins reaction is reported, giving rise to valuable and diverse piperidines and pipecolic acid derivatives in both high yields and as single enantiomers. The creation of a novel chiral auxiliary-homoallylic amine for the aza-silyl-Prins reaction is essential to its success.
