1097201-63-2Relevant academic research and scientific papers
Stereoselective synthesis of novel aristeromycin analogues as potential antiviral agents
Bremond, Paul,Audran, Gerard,Monti, Honore,De Clercq, Erik
, p. 3253 - 3260 (2008)
A series of 3′-methyl-branched and purine-modified analogues of aristeromycin were synthesized via the SN2 displacement of a key triflate, which was prepared from a readily available enantiopure building block in eight steps. The synthesized compounds were evaluated as potential antiviral agents against important viruses. Only the 2,6-diaminopurine derivative exhibited moderate activity against vesicular stomatitis virus.
