109722-87-4Relevant academic research and scientific papers
Synthesis and evaluation of some variants of the Nefkens' reagent
Goodman, Cassie A.,Hamaker, Christopher G.,Hitchcock, Shawn R.
supporting information, p. 6012 - 6014 (2013/10/22)
A series of N-substituted phthalimides have been prepared in an effort to explore synthetic variants of the Nefkens' reagent. Three N-acylphthalimides [R = -CH3, -CH2CH3, and -C(CH3) 3] were prepared and employed for the protection of a series of representative amines. In addition, an N-methanesulfonylphthalimide and N-(diethylphosphoryl)phthalimide were also prepared. It was determined that among the phthalimides that were prepared N-propanoylphthalimide was the most effective reagent for the protection reaction.
