109737-96-4

Basic information

• Product Name: 6-amino-4-chloro-2-(2'-deoxy-3',5'-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl)-2H-pyrazolo<3,4-d>pyrimidine
• Synonyms: 6-amino-4-chloro-2-(2'-deoxy-3',5'-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl)-2H-pyrazolo<3,4-d>pyrimidine
• CAS NO: 109737-96-4
• Molecular Weight: 521.96
• Mol File: 109737-96-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 6-amino-4-chloro-2-(2'-deoxy-3',5'-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl)-2H-pyrazolo<3,4-d>pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-amino-4-chloro-2-(2'-deoxy-3',5'-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl)-2H-pyrazolo<3,4-d>pyrimidine(109737-96-4)
• EPA Substance Registry System: 6-amino-4-chloro-2-(2'-deoxy-3',5'-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl)-2H-pyrazolo<3,4-d>pyrimidine(109737-96-4)

Safety Data

• Hazardous Substances Data: 109737-96-4(Hazardous Substances Data)

Upstream product

• 3056-12-0 2-deoxy-3,5-di-O-(p-toluoyl)-α-D-erythropentofuranosyl chloride 
• 100644-65-3 4-chloro-1H-pyrazolo[3,4-d]pyrimidine-6-amine 
• 5604-46-6 2-amino-4,6-dichloropyrimidine-5-carboxaldehyde 

Downstream Products

• 287177-83-7 C₂₆H₂₅N₅O₅ 

Relevant articles and documents

Synthesis, base pairing, and fluorescence properties of oligonucleotides containing 1H-pyrazolo[3,4-d]pyrimidin-6-amine (8-aza-7-deazapurin-2-amine) as an analogue of purin-2-amine

The synthesis of the N9- and N8-(β-D-2'-deoxyribonucleosides) 2 and 10, respectively, of 8-aza-7-deazapurin-2-amine (=1H-pyrazolo[3,4- d]pyrimidin-6-amine) is described. The fluorescence properties and the stability of the N-glycosylic bond of 2 were determined and compared with those of the 2'-deoxyribonucleosides 1 and 3 of purin-2-amine and 7- deazapurin-2-amine respectively. From the nucleoside 2, the phosphoramidite 14 was prepared, and oligonucleotides were synthesized. Duplexes containing compound 1 or 2 are slightly less stable than those containing 2'- deoxyadenosine, while their CD spectra are rather different. The fluorescence of the nucleosides is strongly quenched (>95%) in single-stranded as well as in duplex DNA. The residual fluorescence was used to determine the melting profiles, which gave T(m) values similar to those determined from the UV melting curves.