109754-25-8

Upstream product

• 186581-53-3 diazomethane 
• 6261-32-1 (E)-2-benzylidene-1-tetralone 

Downstream Products

• 65817-91-6 (1S*,2R*)-6'-methoxy-2-phenyl-3',4'-dihydro-1'H-spiro[cyclopropane-1,2'-naphtalen]-1'-one 
• 138421-94-0 Z-2-(α-methylbenzylidene)-1-tetralone 
• 138421-85-9 E-2-(α-methylbenzylidene)-1-tetralone 

Relevant academic research and scientific papers

Reactions of aliphatic diazo compounds: VI. Reactions of diazomethane and ethyl diazoacetate with (E)-2-arylmethylene-1,2,3,4-tetrahydronaphthalen-1-ones

Diazomethane and ethyl diazoacetate add to (E)-2-arylmethylene-1,2,3,4- tetrahydronaphthalen-1-ones in a regio- and stereoselective fashion, yielding the corresponding 4'-aryl-1,2,3,4,4',5'-hexahydro-3'H-naphthalene-2-spiro-3'- pyrazol-1-ones. The products formed by addition of ethyl diazoacetate undergo isomerization into 4,5-dihydro-1H-pyrazole derivatives.

Synthesis and Stereochemistry of Spiropyrazolines

Spiropyrazolines have been synthesized by 1,3-dipolar cycloaddition of an 2-arylidene-1-tetralone, 3-arylidene-chromanones, -1-thiochromanones, and -flavanones with diazomethane.The relative configuration and stereochemistry of the products have been dete