109765-90-4Relevant academic research and scientific papers
A new route towards fimbrolide analogues: Importance of the exomethylene motif in LuxR dependent quorum sensing inhibition
Sabbah, Mohamad,Bernollin, Maud,Doutheau, Alain,Soulere, Laurent,Queneau, Yves
, p. 363 - 366 (2013)
Sixteen analogues of fimbrolides (brominated 3-substituted-5-methylene- 2(5H)-furanones), naturally occurring bacterial quorum sensing (QS) inhibitors, were synthesized by a novel sequence. The importance of the methylene group, either brominated or non-brominated, in LuxR-dependent QS inhibition was demonstrated. One of the most active furanone-type QS inhibitors was identified, with an IC50 of 0.6 μM. The Royal Society of Chemistry.
