109772-29-4Relevant academic research and scientific papers
ASSYMMETRIC SYNTHESIS OF CYCLIC IMINO ACIDS VIA CHIRAL SCHIFF BASES
Bajgrowicz, Jerzy,Achquar, Abdelrhani El,Roumestant, Marie-Louise,Pigiere, Christian,Viallefont, Philippe
, p. 2165 - 2167 (2007/10/02)
A new method of synthesis of cyclic imino acids is reported.Diastereoselective alkylation of Schiff bases (derived from α-amino esters and (+) or (-) 2-hydroxypinan-3-one) with dihalogeno compounds, followed by hydrolytic cleavage and cyclization affords the imino esters.Reactions are highly enantioselective, with one exception corresponding to steric crowding.
