1097725-69-3

Upstream product

• 1257855-44-9 tert-butyl 6-bromo-2-chloropyridin-3-yl(methyl)carbamate 
• 1365094-34-3 1-methyl-5-phenyl-1H-imidazo[4,5-b]pyridine 
• 1365094-30-9 2-chloro-N-methyl-6-phenylpyridin-3-amine 
• 1365094-52-5 tert-butyl 2-chloro-6-phenylpyridin-3-yl(methyl)carbamate 
• 506-68-3 bromocyane 
• 1097725-78-4 2-amino-3-methylamino-6-phenylpyridine 

Relevant academic research and scientific papers

Synthesis of imidazo[4,5-b]pyridines and imidazo[4,5-b]pyrazines by palladium catalyzed amidation of 2-chloro-3-amino-heterocycles

A facile synthesis of imidazo[4,5-b]pyridines and-pyrazines is described using a Pd-catalyzed amide coupling reaction. This reaction provides quick access to products with substitution at N1 and C2. A model system relevant to the natural product pentosidi

Synthesis and mutagenic potency of structural isomers of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine

(Chemical Equation Presented) Synthesis of 2-amino-1-methyl-6- phenylimidazo[4,5-b]pyridine (PhIP), three structural isomers, and two desphenyl PhIP congeners has been carried out. Mutagenic potency was evaluated using S. typhimurium strain TA98 in the Ames test. Mutagenic potency increased in relation to structural features in these heterocyclic amines that allow extended resonance between the phenyl and imidazo[4,5-b]pyridine N2-amino substituents. By contrast, PhIP isomers, whose substitution disallows involvement of the phenyl group in their ammoimidazo resonance hybrids, and desphenyl congeners were from 86- to 234-fold less mutagenic than PhIP.