109774-63-2

Basic information

• Product Name: C₂₃H₂₄NO₃P
• CAS NO: 109774-63-2
• Molecular Weight: 393.422
• Mol File: 109774-63-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₃H₂₄NO₃P(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₂₄NO₃P(109774-63-2)
• EPA Substance Registry System: C₂₃H₂₄NO₃P(109774-63-2)

Safety Data

• Hazardous Substances Data: 109774-63-2(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 6190-28-9 N,P,P-triphenylphosphinic amide 

Downstream Products

• 3422-01-3 tert-butyl phenylcarbamate 

Relevant articles and documents

A Simple Method for tert-Butoxycarbonylation of Amides

The tert-butoxycarbonyl (Boc) function was conveniently introduced onto the amide nitrogen in several secondary amides using di-tert-butyl dicarbonate in dry acetonitrile with 4-dimethylaminopyridine as catalyst.Carboxamides with different acyl groups such as formyl, acetyl and benzoyl are presented as well as derivatives of carbamic acid.Examples also include other amide types: sulfonamide, sulfenamide and phosphinamide which were all smoothly converted to the corresponding Boc derivatives under these conditions.The yields were generally excellent and the resulting Boc analogues stable compounds which could be stored for months under ordinary conditions.Some stereochemical and structural aspects of this acylation are also discussed.Bulky substituents in the proximity of the amide moiety significantly retarded the reaction and in some cases no product was detected.For one compound with an activated methine group, C acylation was observed.