1097793-34-4

Upstream product

• 13651-14-4 (2,3-dimethylphenyl)methanol 
• 88-74-4 2-nitro-aniline 
• 1187386-91-9 C₁₅H₁₆N₂ 

Relevant academic research and scientific papers

A continuous compound benzene and imidazole compounds

The invention discloses a method for continuously synthesizing a benzimidazole compound. The method comprises the steps:in a fixed bed reactor, firstly reducing and activating a loaded multi-metal solid catalyst by hydrogen; then using inert gas as carrier gas; adjusting the temperature to 130-250 DEG C and the pressure at 2-10 MPa; continuously introducing mixed raw materials of an ortho-nitroaniline compound shown in a formula (I), fatty alcohol shown in a formula (II) and distilled water iknto the fixed bed reactor by using a high pressure pump; feeding the reactants which are cooled by a condenser to a gas-liquid separator to collect a liquid product so as to obtain the benzimidazole compound shown in a formula (III), wherein the loaded multi-metal solid catalyst is a Cu-Pd-M/Al2O3 catalyst. According to the method disclosed by the invention, multiple intermittent reactions are changed to a one-step continuous reaction, so that the production process is simplified, generation of byproducts is reduced, the conversion rate can reach 100% to the maximum extent, and the yield of the target product benzimidazole compound can reach 99% to the maximum extent. The formulae are shown in the description.

Direct imidation to construct 1H-benzo[d]imidazole through Pd II-catalyzed C-H activation promoted by thiourea

A study was conducted to demonstrate the development of a method to construct 1H-benzo[d]immidazole through PdII -catalyzed intermolecular C-H activation starting from N-phenylbenziimidamide. The detailed mechanism investigations indicated that a palladacycle monomer or dimer was the key intermediate for this transformation, demonstrating that thiourea was first used to influence the efficiency of C-H activation. The method was found to construct 1H-benzo[d]immidazole through PdII -catalyzed intermolecular C-H activation extending the substrate scope widely. It also demonstrated the introduction of thiourea (tetramethylthiourea) (TMTU) for the first time as an additive to promote the efficiency of PdII catalysis for the direct C-H transformation. N-phenylbenziimidamide was also readily synthesized through the addition of aniline to benzonitrile according to the method to conduct the investigations.