1097921-59-9

Basic information

• Product Name: 4-chloro-N-[2-(methanesulfonyl)phenyl]-1,3,5-triazin-2-amine
• Synonyms: 4-chloro-N-[2-(methanesulfonyl)phenyl]-1,3,5-triazin-2-amine
• CAS NO: 1097921-59-9
• Molecular Weight: 284.726
• Mol File: 1097921-59-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-chloro-N-[2-(methanesulfonyl)phenyl]-1,3,5-triazin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-N-[2-(methanesulfonyl)phenyl]-1,3,5-triazin-2-amine(1097921-59-9)
• EPA Substance Registry System: 4-chloro-N-[2-(methanesulfonyl)phenyl]-1,3,5-triazin-2-amine(1097921-59-9)

Safety Data

• Hazardous Substances Data: 1097921-59-9(Hazardous Substances Data)

Upstream product

• 2831-66-5 2,4-dichloro-1,3,5-triazine 
• 2987-49-7 2-(methanesulfonyl)aniline monohydrochloride 

Downstream Products

• 1097919-10-2 N-[2-(methanesulfonyl)phenyl]-N'-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}-1,3,5-triazine-2,4-diamine 

Relevant articles and documents

Discovery of N-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}-N′-[2-(propane-2-sulfonyl)phenyl]-1,3,5-triazine-2,4-diamine (ASP3026), a potent and selective anaplastic lymphoma kinase (ALK) inhibitor

Anaplastic lymphoma kinase (ALK) is a validated therapeutic target for treating echinoderm microtubule- associated protein-like 4 (EML4)-ALK positive non-small cell lung cancer (NSCLC). We synthesized a series of 1,3,5-triazine derivatives and identified ASP3026 (14a) as a potent and selective ALK inhibitor. In mice xenografted with NCI-H2228 cells expressing EML4-ALK, once-daily oral administration of 14a demonstrated dose-dependent antitumor activity. Here, syntheses and structure-activity relationship (SAR) studies of 1,3,5-triazine derivatives are described.