1097975-93-3

Upstream product

• 89-98-5 2-chloro-benzaldehyde 
• 120-72-9 indole 
• 2698-41-1 o-chlorobenzylidene malononitrile 
• 109-77-3 malononitrile 

Relevant academic research and scientific papers

[TBA][Gly] ionic liquid promoted multi-component synthesis of 3-substituted indoles and indolyl-4H-chromenes

Tetrabutylammonium glycinate [TBA][Gly] ionic liquid was found to be an efficient recyclable and biodegradable organocatalyst for selective synthesis of 3-substituted indoles and indolyl-4H-chromenes. The reaction between substituted aliphatic/aromatic aldehydes, malononitrile, and indoles in the presence of [TBA][Gly] IL at 60 °C under solvent free conditions afforded 3-substituted indoles in excellent yields. Indolyl-4H-chromenes were achieved in excellent yields by replacing the benzaldehydes with salicylaldehyde under optimized reaction conditions.

H5PW10V2O40@VOx/SBA-15-NH2 catalyst for the solventless synthesis of 3-substituted indoles

Functionalization of mesoporous SBA-15 frameworks by transition metal oxides offers a flexible route to fabricate new heterogeneous catalysts. Here, an inorganic-organic hybrid nanoporous catalyst H5PW10V2O40@VO

Palladium oxide-decorated mesoporous silica on graphene oxide nanosheets as a heterogeneous catalyst for the synthesis of β-substituted indole derivatives

In this work, an efficient and facile strategy has been adopted for the stepwise synthesis of the RGO-MSiO2/PdO hybrid nanomaterial (HY-NM). Herein, a hybrid nanostructure of mesoporous silica over graphene oxide (GO) sheets has been developed

Water assisted and choline chloride-dimethylurea deep eutectic salts as catalyst towards the attractive reaction of indole, benzaldehyde, and malononitrile

The condensation of indole, benzaldehyde, and malononitrile was relatively rigorous compared with other Yonemitsu type reaction. We described a strategy using catalytic amount of choline chloride-dimethylurea deep eutectic salts as cheap and safe accelerator. We also found that introducing right amount of water in reaction system was crucial. This method tolerates variations in all three components to get desired 3-substituted indoles in satisfactory yields.

Morphology controlled phosphate grafted SnO2-ZrO2 nanocomposite oxides prepared by a urea hydrolysis method as efficient heterogeneous catalysts towards the synthesis of 3-substituted indoles

In this study, a series of phosphate grafted SnO2-ZrO2 nanocomposite oxides are prepared via the urea hydrolysis of salt precursors followed by treatment with phosphate ions and calcination. The nanocomposite materials are characteri

Polyethylene glycol (PEG-200)-promoted sustainable one-pot three-component synthesis of 3-indole derivatives in water

A sustainable three-component reaction of indoles, aldehydes, and malononitrile in water promoted by polyethylene glycol (PEG-200) afforded 3-indole derivatives in good to excellent yields.

Synthesis of 3-indole derivatives by copper sulfonato Salen catalyzed three-component reactions in water

An efficient three-component reaction of indole, aldehyde, and malononitrile in water catalyzed by a copper(ii) sulfonato Salen complex afforded 3-indole derivatives in good to excellent yields up to 97%. The Royal Society of Chemistry.