1097975-95-5

Upstream product

• 120-72-9 indole 
• 104-88-1 4-chlorobenzaldehyde 
• 109-77-3 malononitrile 
• 1867-38-5 4-chlorobenzylidenemalonodinitrile 

Relevant academic research and scientific papers

Efficient synthesis of 3-substituted indoles via a base-free copper-catalysed three-component reaction in water

The preparation of sixteen 3-substituted indoles in good to excellent yields under environmentally friendly conditions has been achieved via a three-component reaction in water of an indole, an aldehyde and malononitrile (or ethyl 2-cyanoacetate) catalysed by 5 mol% of 2-pyrrolecarbaldiminato-Cu(II).

Facile synthesis of 3-substituted indoles containing highly polarized double bonds

In this paper, an effective procedure is described for the synthesis of novel indoles containing highly polarized double bonds. The strategy involves the preparation of (indolylmethyl)malononitriles via the one-pot three-component reaction of an aldehyde,

Palladium oxide-decorated mesoporous silica on graphene oxide nanosheets as a heterogeneous catalyst for the synthesis of β-substituted indole derivatives

In this work, an efficient and facile strategy has been adopted for the stepwise synthesis of the RGO-MSiO2/PdO hybrid nanomaterial (HY-NM). Herein, a hybrid nanostructure of mesoporous silica over graphene oxide (GO) sheets has been developed

Water assisted and choline chloride-dimethylurea deep eutectic salts as catalyst towards the attractive reaction of indole, benzaldehyde, and malononitrile

The condensation of indole, benzaldehyde, and malononitrile was relatively rigorous compared with other Yonemitsu type reaction. We described a strategy using catalytic amount of choline chloride-dimethylurea deep eutectic salts as cheap and safe accelerator. We also found that introducing right amount of water in reaction system was crucial. This method tolerates variations in all three components to get desired 3-substituted indoles in satisfactory yields.

Host/guest inclusion system of surfactants with β-cyclodextrin as a viable catalyst for one-pot synthesis of mono- and bis (indolyl)methylmalononitriles in H2O

In this study, encapsulation processes of cetyltrimethylammonium bromide (CTAB) or sodium dodecyl sulfate (SDS) monomers into the cavity of β-cyclodextrin (β-CD) were applied to synthesize mono- and bis (indolyl)methylmalononitrile derivatives by a one-po

Cu(I)-phosphine complex: An efficient catalyst for synthesis of 3-indole derivatives through one-pot MCR under mild conditions

An efficient copper (I) halotriphenylphosphine catalyzed one-pot multicomponent reaction (MCR) of 3-substituted indole derivatives has been developed using a variety of aldehydes (aromatic, aliphatic, and heteroaromatic), indole, and active methylene subs

Morphology controlled phosphate grafted SnO2-ZrO2 nanocomposite oxides prepared by a urea hydrolysis method as efficient heterogeneous catalysts towards the synthesis of 3-substituted indoles

In this study, a series of phosphate grafted SnO2-ZrO2 nanocomposite oxides are prepared via the urea hydrolysis of salt precursors followed by treatment with phosphate ions and calcination. The nanocomposite materials are characteri

Electrochemical approach for synthesis of 3-substituted indole derivatives

An efficient and economical method was developed for synthesis of 3-substituted indole by using electrochemically induced condensation of various aldehyde, indole and malononitrile.

L - proline in catalytic multi-component generating 3 - substituted indole derivative use and method

The invention discloses application and a method of L-proline in catalyzing multiple components to generate a 3-substituted indole derivative. According to the method, under the catalysis of L-proline, a general formula 1, a general formula 2 and a compou