109806-78-2

Basic information

• Product Name: N-(2,3-dimethoxybenzylidene)-2-(3,4-dimethoxyphenyl)ethanamine
• Synonyms: N-(2,3-dimethoxybenzylidene)-2-(3,4-dimethoxyphenyl)ethanamine
• CAS NO: 109806-78-2
• Molecular Weight: 329.396
• Mol File: 109806-78-2.mol

Chemical Properties

• CAS DataBase Reference: N-(2,3-dimethoxybenzylidene)-2-(3,4-dimethoxyphenyl)ethanamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,3-dimethoxybenzylidene)-2-(3,4-dimethoxyphenyl)ethanamine(109806-78-2)
• EPA Substance Registry System: N-(2,3-dimethoxybenzylidene)-2-(3,4-dimethoxyphenyl)ethanamine(109806-78-2)

Safety Data

• Hazardous Substances Data: 109806-78-2(Hazardous Substances Data)

Upstream product

• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 86-51-1 2,3-dimethyoxybenzaldehyde 

Downstream Products

• 2934-97-6 (+/-)-tetrahydropalmatine 
• 113557-32-7 7,8-dimethoxy-3-(2,3-dimethoxybenzyl)-1-methylthio-1,2,4,5-tetrahydrobenzazepin-2-one 
• 113557-31-6 N-(3,4-dimethoxybenzyl)-N-(2,3-dimethoxyphenethyl)-α-(methylsulfinyl)acetamide 
• 113557-30-5 N-(3,4-dimethoxybenzyl)-N-(2,3-dimethoxyphenethyl)-α-(methylthio)acetamide 
• 113575-52-3 7,8-dimethoxy-2-(3,4-dimethoxybenzyl)-4-methylthio-1,2,3,4-tetrahydroisoquinolin-3-one 
• 113557-41-8 7,8-dimethoxy-2-(3,4-dimethoxyphenethyl)-1,2,3,4-tetrahydroisoquinolin-3-one 
• 26067-60-7 2,3,9,10-tetramethoxy-5,8-dihydro-6H-isoquinolino[3,2-α]isoquinoline 
• 3486-67-7 palmatine 
• 47355-66-8 N-(2,3-dimethoxybenzyl)-2-(3,4-dimethoxyphenyl)ethan-1-amine 

Relevant articles and documents

A NEW AND CONVENIENT SYNTHESIS OF PROTOBERBERINE ALKALOIDS: (+/-)-TETRAHYDROPALMATINE, (+/-)-SINACTINE, (+/-)-CANADINE AND-)-STYLOPINE

2,3,9,10-Tetraoxygenated protoberberine alkaloids (14) were efficiently synthesized from the readily available benzaldehyde (2 or 10) via the benzylphenethylamines (11) and 2-phenethylisoquinolin-3-ones (12 or 13).

Synthesis and biological evaluation of some new β-lactam-triazole hybrids

A series of novel β-lactams was synthesized from different imines and a special ketene derived from N-endo-5-norbornene-2,3-dicarboxyloylglycine 1 via the [2 + 2] ketene imine cycloaddition. Then, β-lactams 3a-h were treated with 1-azido-4-nitrobenzene 4

Synthesis and antihyperglycemic evaluation of various protoberberine derivatives

Various berberine derivatives (2-17) were synthesized and their antihyperglycemic activities were evaluated in a model of β-cell-membrane chromatography and a model of alloxan-induced diabetes mice. The results indicated that compounds 5 and 14 exhibited antihyperglycemic activity. Their structure-activity relationships were discussed.

Convenient synthesis of 2,3,9,10-tetraoxygenated protoberberine alkaloids and their 13-methyl alkaloids

New and convenient synthesis of 2,3,9,10-tetraoxygenated protoberberine alkaloids and their 13-methyl alkaloids through the same intermediates was developed. Acylation of the brominated benzylphenethylamine (13) with α- chloro-α-(methylthio)acetyl chloride, followed by cyclization with stannic chloride, furnished the key intermediates 4-methylthio-3- phenethylisoquinolin-3-ones (14), which were methylated to provide their methyl derivatives (17). Both isoquinolin-3-ones (14, 17) were easily transformed into protoberberine alkaloids (16) and their 13-methyl alkaloids (21) in good yield.