109806-79-3Relevant academic research and scientific papers
N-substituted imines by the copper-catalyzed N-imination of boronic acids and organostannanes with O-acyl ketoximes
Liu, Songbai,Yu, Ying,Liebeskind, Lanny S.
, p. 1947 - 1950 (2008/02/02)
Catalytic quantities of copper(I) or copper(II) sources catalyze the N-imination of boronic acids and organostannanes through reaction with oxime O-carboxylates under nonbasic conditions. This method tolerates various functional groups and takes place efficiently using aryl, heteroaryl, and alkenyl boronic acids and stannanes.
Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use
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, (2008/06/13)
Indazole compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction and thereby modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer and other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.
