1098073-26-7

Basic information

• Product Name: 5-(1-(2-fluorophenyl)cyclohexyl)-2,2-dimethyl-1,3-dioxane-4,6-dione
• Synonyms: 5-(1-(2-fluorophenyl)cyclohexyl)-2,2-dimethyl-1,3-dioxane-4,6-dione
• CAS NO: 1098073-26-7
• Molecular Weight: 320.361
• Mol File: 1098073-26-7.mol

Chemical Properties

• CAS DataBase Reference: 5-(1-(2-fluorophenyl)cyclohexyl)-2,2-dimethyl-1,3-dioxane-4,6-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(1-(2-fluorophenyl)cyclohexyl)-2,2-dimethyl-1,3-dioxane-4,6-dione(1098073-26-7)
• EPA Substance Registry System: 5-(1-(2-fluorophenyl)cyclohexyl)-2,2-dimethyl-1,3-dioxane-4,6-dione(1098073-26-7)

Safety Data

• Hazardous Substances Data: 1098073-26-7(Hazardous Substances Data)

Upstream product

• 3709-25-9 5-Cyclohexylidene-2,2-dimethyl-[1,3]dioxane-4,6-dione 
• 446-53-7 2-fluorophenylmagnesium bromide 
• 1072-85-1 o-fluorobromobenzene 

Downstream Products

• 1381982-60-0 1-fluoro-2-(1-methylcyclohexyl)benzene 

Relevant articles and documents

Carbon-based leaving group in substitution reactions: Functionalization of sp3-hybridized quaternary and tertiary benzylic carbon centers

Lewis acid promoted substitution reactions employing Meldrum's acid and 5-methyl Meldrum's acid as carbon-based leaving groups are described which transform unstrained quaternary and tertiary benzylic Csp 3-Csp3 bonds into Csp3-X bonds (X = C, H, N). Importantly, this reaction has a broad scope in terms of both suitable substrates and nucleophiles with good to excellent yields obtained (typically >90%).

Probing persistent intramolecular C-H· · ·X(X = O, S, Br, Cl, and F) bonding in solution using benzyl meldrum's acid derivatives

Persistent intramolecular interactions between acidic C-H hydrogens and a variety of acceptors (X) (X = O, S, Br, Cl, and F) in solution were probed by 1H NMR experiments, using 5-benzyl Meldrum's acid derivatives. To bring about formation of i