1098176-72-7Relevant academic research and scientific papers
Synthetic chalcones as efficient inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase PtpA
Chiaradia, Louise Domeneghini,Mascarello, Alessandra,Purificacao, Marcela,Vernal, Javier,Cordeiro, Marlon Norberto Sechini,Zenteno, Maria Emilia,Villarino, Andrea,Nunes, Ricardo Jose,Yunes, Rosendo Augusto,Terenzi, Hernan
, p. 6227 - 6230 (2008)
In the search for lead compounds for new drugs for tuberculosis, the activity of 38 synthetic chalcones were assayed for their potential inhibitory action towards a protein tyrosine phosphatase from Mycobacterium tuberculosis - PtpA. The compounds were ob
Cytotoxic 3,4,5-trimethoxychalcones as mitotic arresters and cell migration inhibitors
Salum, Lívia B.,Altei, Wanessa F.,Chiaradia, Louise D.,Cordeiro, Marlon N.S.,Canevarolo, Rafael R.,Melo, Carolina P.S.,Winter, Evelyn,Mattei, Bruno,Daghestani, Hikmat N.,Santos-Silva, Maria Cláudia,Creczynski-Pasa, Tania B.,Yunes, Rosendo A.,Yunes, José A.,Andricopulo, Adriano D.,Day, Billy W.,Nunes, Ricardo J.,Vogt, Andreas
, p. 501 - 510 (2013/07/25)
Based on classical colchicine site ligands and a computational model of the colchicine binding site on beta tubulin, two classes of chalcone derivatives were designed, synthesized and evaluated for inhibition of tubulin assembly and toxicity in human canc
Induction of apoptosis and cell cycle arrest in L-1210 murine lymphoblastic leukaemia cells by (2E)-3-(2-naphthyl)-1-(3′-methoxy-4′-hydroxy- phenyl)-2-propen-1-one
Pedrini, Fernanda Spezia,Chiaradia, Louise Domeneghini,Licinio, Marley Aparecida,De Moraes, Ana Carolina Rabello,Curta, Juliana Costa,Costa, Aline,Mascarello, Alessandra,Creczinsky-Pasa, Tania Beatriz,Nunes, Ricardo Jose,Yunes, Rosendo Augusto,Santos-Silva, Maria Claudia
scheme or table, p. 1128 - 1136 (2011/12/04)
Objectives New compounds with biological targets and less cytotoxicity to normal cells are necessary for cancer therapy. In this work ten synthetic chalcones derived from 2-naphtaldehyde were evaluated for their cytotoxic effect in murine acute lymphoblas
Hydroxychalcones induce apoptosis in B16-F10 melanoma cells via GSH and ATP depletion
Navarini, Andreia Lilian Formento,Chiaradia, Louise Domeneghini,Mascarello, Alessandra,Fritzen, Marcio,Nunes, Ricardo Jose,Yunes, Rosendo Augusto,Creczynski-Pasa, Tania Beatriz
experimental part, p. 1630 - 1637 (2009/06/20)
Searching for leading compounds of new drugs for cancer therapy, we studied the toxicity of 13 hydroxychalcones never tested before toward melanoma cell line (B16-F10). The compounds were obtained by aldolic condensation between aldehydes and hydroxylated
