1098215-18-9Relevant articles and documents
The Ugi reaction with CF3-carbonyl compounds: effective synthesis of α-trifluoromethyl amino acid derivatives
Gulevich, Anton V.,Shevchenko, Nikolay E.,Balenkova, Elisabeth S.,R?schenthaler, Gerd-Volker,Nenajdenko, Valentine G.
experimental part, p. 11706 - 11712 (2009/04/06)
The Ugi reaction with CF3-carbonyl compounds is described in detail. The method is efficient for the multicomponent preparation of α-trifluoromethyl (Tfm) amino acids, α-Tfm containing dipeptides, and iminodicarboxylic acids. In addition, the first protected CF3-opine derivative was prepared. The scope, limitations, and stereochemistry of the approach are discussed.