1098336-82-3Relevant academic research and scientific papers
Fluorine-containing heterocycles: Xviii. * monofluoro derivatives of quinazolines and 1,3-benzothiazin-4-ones
Nosova,Laeva,Trashakhova,Golovchenko,Lipunova,Slepukhin,Charushin
, p. 904 - 912 (2009)
5- and 7-Fluoro-substituted quinazolines and 1,3-benzothiazin-4-ones were synthesized starting from 2-amino-6-fluorobenzonitrile and mono- and difluoro-substituted benzoic acid derivatives. The reactivities of di- and tetrafluoro-substituted benzoyl chlorides and benzoyl isothiocyanates in cyclocondensations leading to fluorinated quinazolines and 1,3-benzothiazines were compared. Pleiades Publishing, Ltd., 2009.
Synthesis of 5-and 7-fluoroquinazolin-4(1H)-ones
Layeva,Nosova,Lipunova,Trashakhova,Charushin
, p. 1821 - 1827 (2008/09/19)
5-Fluoroquinazoline-2,4-diones and their 2-thio analogs were obtained from 6-fluoroanthranilic acid. Two convenient routes to 5-fluoroquinazolin-4-ones involved cyclocondensation of 6-fluoroanthranilamide with acid chlorides (anhydrides) or with aromatic (heterocyclic) aldehydes. A method for the synthesis of 7-fluoroquinazolin-4-one from 2,4-difluorobenzoic acid was proposed.
