1098340-27-2 Usage
Description
Methyl 4-(trifluoromethyl)-1H-indole-2-carboxylate is a chemical compound with the molecular formula C12H8F3NO2. It is an organic compound that belongs to the indole family. Indoles are aromatic heterocyclic compounds that can perform various chemical reactions. This particular compound has a trifluoromethyl group, which can improve biological activity in pharmaceuticals and represents a key structural motif in medicinal chemistry. It also has a carboxylate group, which is a strong donor of resonance in chemical structures, potentially further enhancing its reactivity and utility in chemical synthesis.
Uses
Used in Pharmaceutical Industry:
Methyl 4-(trifluoromethyl)-1H-indole-2-carboxylate is used as a key intermediate in the synthesis of various pharmaceutical compounds for its potential to improve biological activity. The presence of the trifluoromethyl group and carboxylate group in its structure makes it a valuable building block in the development of new drugs.
Used in Chemical Synthesis:
Methyl 4-(trifluoromethyl)-1H-indole-2-carboxylate is used as a reagent in chemical synthesis processes due to its reactivity and the strong resonance donation provided by the carboxylate group. This allows for the creation of a wide range of chemical products with potential applications in various industries.
The specific applications and toxicity of this compound are dependent on further research.
Check Digit Verification of cas no
The CAS Registry Mumber 1098340-27-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,9,8,3,4 and 0 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1098340-27:
(9*1)+(8*0)+(7*9)+(6*8)+(5*3)+(4*4)+(3*0)+(2*2)+(1*7)=162
162 % 10 = 2
So 1098340-27-2 is a valid CAS Registry Number.
1098340-27-2Relevant articles and documents
Synthesis of chromeno[3,4-b]indoles as Lamellarin D analogues: A novel DYRK1A inhibitor class
Neagoie, Cleopatra,Vedrenne, Emeline,Buron, Frédéric,Mérour, Jean-Yves,Rosca, Sorin,Bourg, Stéphane,Lozach, Olivier,Meijer, Laurent,Baldeyrou, Brigitte,Lansiaux, Amelie,Routier, Sylvain
, p. 379 - 396 (2012/04/10)
A library of substituted chromeno[3,4-b]indoles was developed as Lamellarin isosters. Synthesis was achieved from indoles after a four-step pathway sequence involving C-3 iodination, a Suzuki cross-coupling reaction, and a one pot deprotection/lactonisation step. Twenty final compounds were tested in order to determine their activity against topoisomerase I and kinases, the two major biological activities of Lamellarins. One newly synthesized derivative exhibited a strong topoisomerase activity comparable to reference compounds such as campthotecin and Lamellarin with only a weak kinase inhibition. Two other lead compounds were identified as new nanomolar DYRK1A inhibitors and several other drugs affected the kinases in the sub-micromolar range. These results will enable us to use the chromeno[3,4-b]indole as a pharmacophore to develop potent treatments for neurological or oncological disorders in which DYRK1A is fully involved.