1098358-37-2Relevant academic research and scientific papers
Synthesis and electrochemical behavior of triazole-containing nicotinamide adenine dinucleotide analogs
Liu, Wujun,Hou, Shuhua,Zhao, Zongbao Kent
experimental part, p. 35 - 41 (2010/03/04)
The coupling of 2′,3′-di-O-acetyl nicotinamide mononucleotide with 3-butyn-1-ol in the presence of 2,4,6- triisopropylbenzenesulfonyl chloride quantitatively afforded a terminal alkyne-containing intermediate. Furthermore, copper(I)-mediated Huisgen [3 + 2] cycloaddition with a series of azido compounds in a two-phase solvent system gave eight triazole-containing nicotinamide adenine dinucleotide analogs with yields over 88%. The cyclic voltammetric behaviors of these novel analogs were investigated with a glassy carbon electrode, and structural features of these analogs on their electrochemical properties were briefly discussed.
