1098589-87-7Relevant articles and documents
Preparation of complexes of 1-amino-6,7-O-cyclohexylidene-4-azaheptane with transition metal acetates
Oeztirk,Sekerci,Oezdemir
, p. 33 - 36 (2006)
1-Amino-6,7-O-cyclohexylidene-4-azaheptane (L) has been synthesized starting from 1-chloro-2,3-O-cyclohexylidenepropane prepared by the reaction of epichlorohydrin with cyclohexanone, catalyzed by BF3OEt2. Complexes of this ligand with Co(II), Ni(II) and Cu(II) acetates were prepared. The structures of the ligand and its complexes are proposed based on the elemental analyses, IR, UV-VIS, and 1H and 13C NMR spectra, magnetic susceptibilities, and conductomety data. Pleiades Publishing, Inc. 2006.
1,3-Dioxolane-based ligands as a novel class of α1-adrenoceptor antagonists
Brasili, Livio,Sorbi, Claudia,Franchini, Silvia,Manicardi, Massimo,Angeli, Piero,Marucci, Gabriella,Leonardi, Amedeo,Poggesi, Elena
, p. 1504 - 1511 (2007/10/03)
1,3-Dioxolane-based compounds (2-14) were synthesized, and the pharmacological profiles at α1-adrenoceptor subtypes were assessed by functional experiments in isolated rat vas deferens (α1A), spleen (α1B), and aorta (α1D). Compound 9, with a pA2 of 7.53, 7.36, and 8.65 at α1A, α1B, and α1D, respectively, is the most potent antagonist of the series, while compound 10 with a pA2 of 8.37 at α1D subtype and selectivity ratios of 162 (α1D/α1A) and 324 (α1D/α1B) is the most selective. Binding assays in CHO cell membranes expressing human cloned α1-adrenoceptor subtypes confirm the pharmacological profiles derived from functional experiments, although the selectivity values are somewhat lower. Therefore, it is concluded that 1,3-dioxolane-based ligands are a new class of α1-adrenoceptor antagonists.
PERFLUORINATED RESINSULFONIC ACID - A CATALYST FOR CERTAIN ORGANIC REACTIONS.
Etlis,Beshenova,Semenova,Shomina,Dreiman,Balaev
, p. 551 - 555 (2007/10/02)
The purpose of this work was to examine the possibility of using, as a catalyst in certain organic reactions, the perfluorinated resinsulfonic acid F-4SK in the H form, which is an analog of the perfluorinated resinsulfonic acid Nafion-H. To compare catalyst activity of the perfluorinated resinsulfonic acid in decomposition of cumene hydroperoxide, CHP was also decomposed in presence of KU-2 resin. It was found that during repeated use over a period of 150 h the activity of KU-2 catalyst under analogous conditions fell by 4-6%. During the same time the activity of the perfluorinated resinsulfonic acid remained unchanged. It is also known that the presence of a strong acid in the reaction mixture causes formation of by-products, namely the products of condensation of phenol with acetone and dimethylphenylcarbinol, and of dehydration of dimethylphenylcarbinol, with formation of alpha -methylstyrene and products of greater complexity.