109864-27-9Relevant academic research and scientific papers
syn-Selctive Michael Addition of Lithiated 2-Alkoxyacetates and -acetamides to α,β-Unsaturated Carbonyl Compounds
Kanemasa, Shuji,Nomura, Masafumi,Wada, Eiji
, p. 1735 - 1738 (2007/10/02)
The lithium Z-enolates derived from 2-alkoxyacetates and -acetamides undergo unusual syn-selective Michael addition to α,β-unsaturated carbonyl compounds, where the syn selectivity of the amide enolates is much higher than that of the ester enolates.Factors that influence the stereoselectivity are also discussed.
