109865-03-4

Basic information

• Product Name: [(S)-1-[(1S,2S)-1-Cyclohexylmethyl-2-hydroxy-4-(propane-2-sulfonyl)-butylcarbamoyl]-2-(1H-imidazol-4-yl)-ethyl]-carbamic acid tert-butyl ester
• Synonyms: [(S)-1-[(1S,2S)-1-Cyclohexylmethyl-2-hydroxy-4-(propane-2-sulfonyl)-butylcarbamoyl]-2-(1H-imidazol-4-yl)-ethyl]-carbamic acid tert-butyl ester
• CAS NO: 109865-03-4
• Molecular Weight: 528.714
• Mol File: 109865-03-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [(S)-1-[(1S,2S)-1-Cyclohexylmethyl-2-hydroxy-4-(propane-2-sulfonyl)-butylcarbamoyl]-2-(1H-imidazol-4-yl)-ethyl]-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [(S)-1-[(1S,2S)-1-Cyclohexylmethyl-2-hydroxy-4-(propane-2-sulfonyl)-butylcarbamoyl]-2-(1H-imidazol-4-yl)-ethyl]-carbamic acid tert-butyl ester(109865-03-4)
• EPA Substance Registry System: [(S)-1-[(1S,2S)-1-Cyclohexylmethyl-2-hydroxy-4-(propane-2-sulfonyl)-butylcarbamoyl]-2-(1H-imidazol-4-yl)-ethyl]-carbamic acid tert-butyl ester(109865-03-4)

Safety Data

• Hazardous Substances Data: 109865-03-4(Hazardous Substances Data)

Upstream product

• 109864-89-3 (2S,3S)-2-amino-1-cyclohexyl-3-hydroxy-5-(isopropylsulfonyl)pentane 
• 17791-52-5 N-(tert-butoxycarbonyl)-L-histidine 
• 104856-08-8 (4S,5S)-4-(cyclohexylmethyl)-5-vinyloxazolidin-2-one 
• 109864-84-8 (4S,5S)-4-(cyclohexylmethyl)-5-<2-(mesyloxy)ethyl>oxazolidin-2-one 
• 109864-87-1 (4S,5S)-4-(cyclohexylmethyl)-5-<2-(isopropylsulfonyl)ethyl>oxazolidin-2-one 
• 109864-85-9 (4S,5S)-4-(cyclohexylmethyl)-5-<2-(isopropylthio)ethyl>oxazolidin-2-one 
• 109864-83-7 (4S,5S)-4-(cyclohexylmethyl)-5-(2-hydroxyethyl)oxazolidin-2-one 
• 98105-41-0 methyl S-3-cyclohexyl-2-(t-butoxycarbonylamino)propionate 

Relevant articles and documents

Renin Inhibitors. Dipeptide Analogues of Angiotensinogen Incorporating Transition-State, Nonpeptidic Replacements at the Scissile Bond

A series of dipeptide analogues of angiotensinogen have been prepared and evaluated for their ability to inhibit the aspartic proteinase renin.The compounds were derived from the renin substrate by replacing the scissile amide bond with a transition-state mimic and by incorporating bioisosteric replacements for the Val-10 amide bond.Analogue 21a exhibited an IC50 of 7.6 nM against purified human renin, showed high specificity for this enzyme, and produced a hypotensive response in anesthetized, salt-depleted cynomolgus monkeys.