109882-26-0Relevant articles and documents
Preparation method and applications of bendamustine hydrochloride dimer
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Paragraph 0023; 0024; 0025, (2016/10/31)
The present invention relates to a preparation method and applications of a bendamustine hydrochloride dimer represented by a formula III. The preparation method comprises that bendamustine hydrochloride reacts with monohydroxyphenyl bendamustine hydrochloride under the conditions of a catalyst and a condensation agent to obtain the bendamustine hydrochloride dimer (represented by the formula III). According to the present invention, the compound represented by the formula III can be adopted as the control substance for the bendamustine hydrochloride related substance detection, and can further be used for the purity control of the bendamustine hydrochloride raw material or bendamustine hydrochloride preparation.